GENERAL OUTLINE FOR
EFFECTS OF EXPOSURE TO ENVIRONMENTAL TOXINS
EVHS 401-B Spring

Instructor - Martina Veigl

UCRC Bldg. 2, Suite 200

216-844-7525

Lecture 1 & 2 General Introduction to Course

UV Radiation

Types of UV Radiation, Biological Effects of UV Radiation, Factors Affecting UV Exposure, Lesions at DNA Level, Repair of Lesion

Lecture 3 & 4 Electromagnetic Waves

Sources and Levels of Exposure, Evaluate Danger of Exposure

Ionizing Radiation

Types of Radiation, Units of Radiation Measurement, Properties of Radionucleotides, Biological Effects of Radiation, Average Radiation Exposure and Sources of Radiation, Everyday Risks for Exposure to Radiation, Examples & Consequences of High Level Radiation Exposure, Ways to Monitor Radiation Exposure, Examples & Consequences of Low Level Radiation Exposure, Lesions at DNA Level, Repair of Lesions

Lecture 5 Industrial Mutagens - Dioxin, Polychlorinated Biphenyl, etc.

Overview, Avenues of Exposure, Acute Toxicity, Genotoxicity

Lecture 6 & 7 Health Effects of Environmental Estrogens

Classes will taught by Dr. Ellen Rorke

Lecture 8 Cigarette Smoke

Epidemiology Studies: Exposure and Genetic Susceptiblity, Mutation Studies in T-Lymphocytes in Smokers versus non-Smokers, Analysis of Mutation Profiles at the DNA Sequence Level, Reporter Gene in Tissue Culture Assays, Oncogenes from Tumor Tissues

Lecture 9 SPRING BREAK
Lecture 10 MIDTERM EXAM
Lecture 11 & 12 Genotoxins and Food

Sources of Potential Food Mutagens, Correlation Between Exposure and Disease, Analysis of DNA Adducts, Mutation Freq. & Mutation Types, Anticarcinogens, Epidemiology Studies: Genetic Susceptibility and Diet

Lecture 13 & 14 Cytotoxicity and Genotoxicity of Heavy Metals

Properties of Lead, Chromium and Mercury are Reviewed, Physiologic Effects of Heavy Metals are Explored, Mutagenic Potential of these Heavy Metals in Standard Mutation Assays are Evaluated, Routes of Exposure - Chronic versus Acute Exposure

Lecture 15 & 16 Microbial and Other Infectious Agents

Viruses [i.e. Hemorrhagic Fever, Ebola, etc.], Nosocomial Infections [i.e. Tuberculosis, etc.], Legionnaire's Disease, Development of Resistant Organisms

Lecture 17 FINAL EXAM

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